City of Saints is a casino/hotel resort; it contains a pool and helipad on the rooftop, slot machines, casino counters, and an emergency exit, and serves as Frank Veliano's homebase.
- This location's name is a reference to the previous game in the series, Gangstar Rio: City of Saints (its name is inspired by said game's subtitle). Also, coincidentally, Gangstar Vegas was released two years after Gangstar Rio: City Of Saints (which was released in 2011).
- At (probably) the Gangstar Vegas "minisite" (probably at Gameloft's official website), its name is given as Casino Rio.
- This is the only location in Gangstar Vegas with a rooftop pool and a helipad/heliport.
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